Галвокимиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2648456-30-6

immunoglobulin G1(VH-CH1-h)-scFv_L-kappa-scFv, anti-[Homo sapiens IL17A (interleukin 17A, IL-17A) and IL17F (interleukin 17F, IL-17F)], anti-[Homo sapiens IL13 (interleukin 13, IL-13)], anti-[Homo sapiens ALB (albumin, human serum albumin, HAS], humanized monoclonal antibody, trispecific, trivalent;
Fused G1(VH-CH1-h)-scFv heavy-kappa heavy chain humanized (1-492) [VH-IGHG1 CH1-h anti-IL-17A/F humanized (1-228) [VH (Homo sapiens IGHV3-7*01 (88.7%) -(IGHD) -IGHJ6*01 (90.9%) T123>L (120), CDR-IMGT [8.8.18] (26-33.51-58.97-114)) (1-125) -Homo sapiens IGHG1*01, G1m17 CH1 K120 (CH1 K120 (222) (126-223), hinge 1-5 (224-228) (126-228))] -11-mer (seryl-tetraglycyl-threonyl-tetraglycyl-seryl) linker (229-239) -scFv heavy-kappa anti-ALB humanized, scFv-v1 C49 (VH)-C120 (VL) (240-492) [VH (Homo sapiens IGHV3-23*01 (78.6%) -(IGHD) -IGHJ2*01 (93.3%), C49 (283), CDR-IMGT [8.7.15] (265-272.290-296.335-349)) (240-360) -20-mer tetrakis(tetraglycyl-seryl) linker (361-380) -V-KAPPA (Homo sapiens IGKV1-12*01 (86.5%) -(IGHD) -IGKJ1*01 (90.9%) C120 (483), CDR-IMGT [7.3.11] (407-413.431-433.470-480)) (381-492)]], (228-214')-disulfide with the fused L-kappa-scFv heavy-kappa light chain humanized (1'-469') [L-kappa anti-IL-17A/F humanized (1'-215') [V-KAPPA (Homo sapiens IGKV1-13*02 (80.0%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')] -11-mer seryl-bis(tetraglycyl-seryl) linker (215'-225') -scFv heavy-kappa anti-IL13 humanized, scFv-v1 C49 (VH)-C120 (VL) (226'-469') [VH (Homo sapiens IGHV1-69*08 (81.6%) -(IGHD) -IGHJ1*01 (100%), C49 (269'), CDR-IMGT [8.8.9] (251'-258'.276'-283'.322'-330')) (226'-341') -20-mer tetrakis(tetraglycyl-seryl) linker (342'-361') -V-KAPPA (Homo sapiens IGKV1-NL1*01 (83.9%) -(IGHD) -IGKJ2*01 (91.7%), C120 (460'), CDR-IMGT [6.3.8] (388'-393'.411'-413'.450'-457')) (362'-469')]], produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, non-glycosylated

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