Гануламеран

Rec. INN (наименование, зарегистрированное ВОЗ)

messenger RNA (mRNA), 5'-capped, encoding the codonoptimised receptor binding domain (RBD) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2, GenBank: MN908947.3) spike (S) glycoprotein expressed as a fusion protein, 5' with an extended S glycoprotein signal peptide, and 3' with a T4 fibritin trimerization domain and the S glycoprotein transmembrane domain (TM) connected by two glycine/serine-rich (GS) linker peptides, flanked by 5' and 3' untranslated regions and a 3' poly(A) tail; contains N1-methylpseudouridine instead of uridine (all-U>m¹ Ψ).

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