Гаривулимаб
GarivulimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2342597-81-1
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CD274 (programmed death ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-446) [VH humanized (Homo sapiens IGHV3-NL1*01 (84.7%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.7.11] (26-33.51-57.96-106) (1-117) -Homo sapiens IGHG1*01 G1m17,1, G1v4 CH2 A114 (CH1 K120 (214) (118-215), hinge 1-15 (216-230) -CH2 V1.2>A (234), P114>A (329) (231-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (118-446)], (220-215')-disulfide with kappa light chain humanized (1’-215’) [V-KAPPA humanized (Homo sapiens IGKV1-5*03 (84.0%) -IGKJ2*01 (91.7%)) CDR-IMGT [6.3.10] (27-32.50-52.89-98) (1'-108') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (226-226":229-229")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
gamma1 heavy chain humanized (1-446) [VH humanized (Homo sapiens IGHV3-NL1*01 (84.7%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.7.11] (26-33.51-57.96-106) (1-117) -Homo sapiens IGHG1*01 G1m17,1, G1v4 CH2 A114 (CH1 K120 (214) (118-215), hinge 1-15 (216-230) -CH2 V1.2>A (234), P114>A (329) (231-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (118-446)], (220-215')-disulfide with kappa light chain humanized (1’-215’) [V-KAPPA humanized (Homo sapiens IGKV1-5*03 (84.0%) -IGKJ2*01 (91.7%)) CDR-IMGT [6.3.10] (27-32.50-52.89-98) (1'-108') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (226-226":229-229")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
Структура
Иностранные названия
- Garivulimabum (латинское)
- Garivulimab (английское)
- Garivulimab (немецкое)
- Garivulimab (французское)
- Garivulimab (испанское)
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