Гарвелейцел

Rec. INN (наименование, зарегистрированное ВОЗ)

Allogeneic T cell-enriched leukocyte preparation, devoid of alloreactive T cells.
The cells are derived from peripheral blood mononuclear cells (PBMCs) collected by apheresis from a haploidentical stem cell donor.
The cells are lymphocyte enriched, and during processing patient and donor cells are co-cultured ex vivo in an MLR (mixed lymphocyte reaction) to stimulate activation of host alloreactive T-cells and subsequent depletion of these cells using a proprietary rhodamine-based photodynamic treatment. In this process, monocytes are largely eliminated from the cell mixture.
The cells are primarily T cells (average ~90%) consisting of both CD4+ T-helper cells and CD8+ Tcytotoxic cells (mean CD4:CD8 ratio of 2.1), and other leucocytes (average ~10%, with B-cells (~ 6-7%) and NK cells (~ 2-3%).

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