Гатипотузумаб
GatipotuzumabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
1264737-26-9
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens MUC1 (mucin 1, polymorphic epithelial mucin, PEM, episialin, CD227) tumor antigen TA-MUC1 conformational epitope O-glycosylated on the threonine of the immunodominant PDTRP motif of the tandem repeats], humanized monoclonal antibody;
gamma1 heavy chain (1-447) [humanized VH (Homo sapiens IGHV3-72*01 (85.00%) -(IGHD)-IGHJ4*01) [8.10.8] (1-117) -Homo sapiens IGHG1*07p, G1m17,1,2 (CH1 K120 (214) (118-215), hinge (216-230),CH2 (231- 340), CH3 D12 (356), L14 (358), G110 (431) (341-445), CHS (446-447)) (118-447)], (220-219')-disulfide with kappa light chain (1'-219') [humanized V-KAPPA (Homo sapiens IGKV2-28*01 (86.00%) -IGKJ1*01) [11.3.9] (1'-112') - Homo sapiens IGKC*01, Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (226-226":229-229")-bisdisulfide
gamma1 heavy chain (1-447) [humanized VH (Homo sapiens IGHV3-72*01 (85.00%) -(IGHD)-IGHJ4*01) [8.10.8] (1-117) -Homo sapiens IGHG1*07p, G1m17,1,2 (CH1 K120 (214) (118-215), hinge (216-230),CH2 (231- 340), CH3 D12 (356), L14 (358), G110 (431) (341-445), CHS (446-447)) (118-447)], (220-219')-disulfide with kappa light chain (1'-219') [humanized V-KAPPA (Homo sapiens IGKV2-28*01 (86.00%) -IGKJ1*01) [11.3.9] (1'-112') - Homo sapiens IGKC*01, Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (226-226":229-229")-bisdisulfide
Структура
Иностранные названия
- Gatipotuzumabum (латинское)
- Gatipotuzumab (английское)
- Gatipotuzumab (французское)
- Gatipotuzumab (испанское)
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