Гавокабтаген аутолейцел
Gavocabtagene autoleucelМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Химическое название
Autologous T cells transduced ex vivo with a self-inactivating lentiviral vector encoding an anti-mesothelin (MSLN) chimeric antigen receptor
Autologous T cells transduced ex vivo with a non-replicating, self-inactivating (SIN) lentiviral vector, encoding an antimesothelin (MSLN) single-domain antibody (sdAb) based chimeric antigen receptor with a leader sequence derived from granulocyte-macrophage colony-stimulating factor receptor alpha (GMCSFR-alpha), fused to the CD3ε subunit of the Tcell receptor (TCR) via an A3(G4S)3LE flexible linker, which is incorporated into the endogenous TCR complex upon expression. The transgene is under control of elongation factor-1 alpha (EF-1α) promoter and woodchuck hepatitis virus post-transcriptional regulatory element. The vector genome also contains a packaging signal, a partial gag sequence, a Rev Response Element (RRE), a central polypurine tract (cPPT) and a 3' polypurine tract (3'PPT).
Autologous T cells transduced ex vivo with a non-replicating, self-inactivating (SIN) lentiviral vector, encoding an antimesothelin (MSLN) single-domain antibody (sdAb) based chimeric antigen receptor with a leader sequence derived from granulocyte-macrophage colony-stimulating factor receptor alpha (GMCSFR-alpha), fused to the CD3ε subunit of the Tcell receptor (TCR) via an A3(G4S)3LE flexible linker, which is incorporated into the endogenous TCR complex upon expression. The transgene is under control of elongation factor-1 alpha (EF-1α) promoter and woodchuck hepatitis virus post-transcriptional regulatory element. The vector genome also contains a packaging signal, a partial gag sequence, a Rev Response Element (RRE), a central polypurine tract (cPPT) and a 3' polypurine tract (3'PPT).
Структура
Иностранные названия
- Gavocabtagenum autoleucelum (латинское)
- Gavocabtagene autoleucel (английское)
- Gavocabtagen autoleucel (немецкое)
- Gavocabtagène autoleucel (французское)
- Gavocabtagén autoleucel (испанское)
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