Генглеуцел

Rec. INN (наименование, зарегистрированное ВОЗ)

allogeneic memory-like natural killer (NK) cells derived after cytokine induction from peripheral blood mononuclear cells (PBMCs) of HLA-haploidentical donors. The PBMCs are depleted of CD3+ cells and cultured in media containing interleukin 15 and 21 (IL-15, IL-21), hydrocortisone and fetal bovine serum (FBS) to induce trans-differentiation.
The final cell population consists of NK cells (CD3-CD56+ >80%), expressing CD122 (>80%) and does not contain CD3+ cells (<5%). The cells can produce perforin 1 and granzyme and demonstrate cytotoxicity against myelogenous leukemia cells in vitro (≥50%)

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