Гептанолимаб
GeptanolimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB16417
CAS
2348469-43-0
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], monoclonal antibody;
gamma4 heavy chain (1-440) [VH (Homo sapiens IGHV7-4-1*02 (85.7%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.7] (26-33.51-58.97-103) (1-114) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (115-212), hinge 1-12 S10>P (222) (213-224), CH2 (225-334), CH3 (335-439), CHS K>del (440) (115-440)], (128-217')-disulfide with kappa light chain (1'-217') [V-KAPPA (Mus musculus IGKV3-5*01 (89.9%) -IGKJ1*01 (90.9%)/Homo sapiens IGKV3D-11*02 (64.9%) -IGKJ2*01 (100%)) CDR-IMGT [10.3.8] (27-36.54-56.93-100) (1'-110') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (156), V101 (194) (111’-217’)]; dimer (220-220":223-223")-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-S cell line, glycoform alfa
gamma4 heavy chain (1-440) [VH (Homo sapiens IGHV7-4-1*02 (85.7%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.7] (26-33.51-58.97-103) (1-114) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (115-212), hinge 1-12 S10>P (222) (213-224), CH2 (225-334), CH3 (335-439), CHS K>del (440) (115-440)], (128-217')-disulfide with kappa light chain (1'-217') [V-KAPPA (Mus musculus IGKV3-5*01 (89.9%) -IGKJ1*01 (90.9%)/Homo sapiens IGKV3D-11*02 (64.9%) -IGKJ2*01 (100%)) CDR-IMGT [10.3.8] (27-36.54-56.93-100) (1'-110') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (156), V101 (194) (111’-217’)]; dimer (220-220":223-223")-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-S cell line, glycoform alfa
Структура
Иностранные названия
- Geptanolimabum (латинское)
- Geptanolimab (английское)
- Geptanolimab (немецкое)
- Geptanolimab (французское)
- Geptanolimab (испанское)
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