Гивастомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2762499-30-7

immunoglobulin G1-scFv_L-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, SFTPJ, surfactant associated protein J) isoform 2, extracellular domain 1 (EC1)], anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily member 9, 4-1BB, T cell antigen ILA, CD137)], humanized monoclonal antibody, bispecific, agonist;
Fused G1-scFv lambda-heavy heavy chain humanized (1-716) [gamma1 heavy chain anti-CLDN18 humanized (1-450) [VH (Homo sapiens IGHV1-3*01 (85.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, IGHG1v29 CH2 A84.4 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 N84.4>A (300) (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)] -15-mer tris(tetraglycyl-seryl) linker (451-465) -scFv lambda-heavy anti-TNFRSF9 humanized, scFv-v2 C120 (VL)-C49 (VH) (466-716) [V-LAMBDA (Homo sapiens IGLV1-47*02 (91.8%) -IGLJ2*01 (90.9%), C120 (568), CDR-IMGT [8.3.11] (491-498.516-518.555-565)) (466-575) -20-mer tetrakis(tetraglycyl-seryl) linker (576-595) -VH (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ4*01 (100%), C49 (639), CDR-IMGT [8.8.14] (621-628.646-653.692-705)) (596-716)]]; (223-220')-disulfide with kappa light chain anti-CLDN18 humanized (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (88.1%) -IGKJ2*01 (91.7%) Q120>G (106'), CDR-IMGT [12.3.9] (27'-38'.56'-58'.95'-103')) (1'-113') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (159'), V101 (197') (114'-220')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, non-glycosylated

Поделиться этой страницей