Глембатумумаб ведотин
Glembatumumab vedotinМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB05996
CAS
1182215-65-1
Химическое название
immunoglobulin G2-kappa, anti-[Homo sapiens GPNMB (glycoprotein (transmembrane) nmb, glycoprotein transmembrane NMB, glycoprotein nonmetastatic melanoma protein B, CG56972, osteoactivin, hematopoietic growth factor inducible neurokinin-1 type, HGFIN) extracellular domain], Homo sapiens monoclonal antibody conjugated to auristatin E;
gamma2 heavy chain (1-445) [Homo sapiens VH (IGHV4- 31*02 (94.90%) -(IGHD)-IGHJ4*01) [10.7.11] (1-119) - IGHG2*01, G2m.. (CH1 (120-217), hinge (218-229), CH2 (230-338), CH3 (339-443), CHS (444-445)) (120-445)], (133-215')-disulfide with kappa light chain (1'-215') [Homo sapiens V-KAPPA (IGKV3-15*01 (96.80%) -IGKJ1*01) [6.3.10] (1'-108') -IGKC*01, Km3 (109'-215')]; dimer (221- 221'':222-222'':225-225'':228-228'')-tetrakisdisulfide; conjugated, on an average of 5 cysteinyl, to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinylp-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker
gamma2 heavy chain (1-445) [Homo sapiens VH (IGHV4- 31*02 (94.90%) -(IGHD)-IGHJ4*01) [10.7.11] (1-119) - IGHG2*01, G2m.. (CH1 (120-217), hinge (218-229), CH2 (230-338), CH3 (339-443), CHS (444-445)) (120-445)], (133-215')-disulfide with kappa light chain (1'-215') [Homo sapiens V-KAPPA (IGKV3-15*01 (96.80%) -IGKJ1*01) [6.3.10] (1'-108') -IGKC*01, Km3 (109'-215')]; dimer (221- 221'':222-222'':225-225'':228-228'')-tetrakisdisulfide; conjugated, on an average of 5 cysteinyl, to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinylp-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker
Структура
Иностранные названия
- Glembatumumabum vedotinum (латинское)
- Glembatumumab vedotin (английское)
- Glembatumumab vedotin (немецкое)
- Glembatumumab védotine (французское)
- Glembatumumab vedotina (испанское)
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