Гокатамиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2851862-91-2

immunoglobulin single chain scFvhl-VH-VH', anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], anti-[Homo sapiens ALB (albumin, human serum albumin, HSA)] and anti-[Homo sapiens DLL3 (delta-like ligand 3, delta like canonical Notch ligand 3)], trispecific;
IG single chain scFvhl-VH-VH' (1-505) [scFvhl anti-CD3E (1-149) [VH Musmus/Homsap (Mus musculus IGHV10-1*02 (89.9%) -(IGHD) -IGHJ3*01 (100%)/Homo sapiens IGHV3-73*01 (85.0%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.10.16] (26-33.51-60.99-114)) (1-125) -15-mer-tris(tetraglycyl-seryl) linker (126-140) -V-LAMBDA (Homo sapiens IGLV7-43*01 (86.2%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (166-174.192-194.231-239)) (141-249)] -9-mer-tetraglycyl-seryl-triglycyl-seryl linker (250-258) -VH anti-ALB (Homo sapiens IGHV3-23*04 (88.5%) -(IGHD) -IGHJ1*01 (81.8%) W118>S (363), G119>S (364), CDR-IMGT [8.8.8] (284-291.309-316.355-362)) (259-373) -9-mer-tetraglycyl-seryl-triglycyl-seryl linker (374-382) -VH anti-DLL3 Vicpac /Homsap (Vicugna pacos IGHV3S53*01 (77.3%) -(IGHD) -IGHJ5*01 (100%)/Homo sapiens IGHV3-7*01 (77.1%) -(IGHD) -IGHJ4*01 (100%), (CDR-IMGT [8.7.11] (408-415.433-440.478-488)) (383-499) -hexahistidine tag (500-505)], produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, lacking the enzyme dihydrofolate reductase (DHFR), non-glycosylated

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