Готистобарт

Rec. INN (наименование, зарегистрированное ВОЗ)

2226344-78-9

immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte-associated protein 4, CTLA-4, CD152)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-454) [VH (Homo sapiens IGHV4-59*01 (86.6%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.7.19] (26-33.51-57.96-114)) (1-125) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120 CH3 D12, L14, G1v6 CH2 A85.4, A118, A119, G1v21 CH2 Y15.1, T16, E18 (CH1 K120 (222) (126-223), hinge 1-15 (224-238), CH2 M15.1>Y (260), S16>T (262), T18>E (264), S85.4>A (306), E118>A (341), K119>A (342) (239-348), CH3 D12 (364), L14 (366) (349-453), CHS K2>del (454)) (126-454)], (228-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (84.2%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')]; dimer (234-234'':237-237'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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