Грутицибарт

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

immunoglobulin G4-kappa, anti-[Homo sapiens F11 (coagulation factor XI, FXI, plasma thromboplastin antecedent, PTA)], monoclonal antibody;
gamma4 heavy chain (1-443) [VH Musmus/Homsap (Mus muculus IGHV2-6-7*01 (83.5%) -(IGHD) -IGHJ2*01 (92.3%) L124>V (112)/Homo sapiens IGHV4-38-2*02 (76.5%) -(IGHD) -IGHJ4*01 (92.3%) L123>T (111), [8.7.10] (26-33.51-57.96-105) (1-116) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10 (CH1 (117-214), hinge 1-12 S10>P (224) (215-226), CH2 L92 (305) (227-336), CH3 (337-441), CHS (442-443)) (117-443)], (130-214')-disulfide with kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV6-17*01 (82.1%) -IGKJ2*01 (83.3%) L124>V (104')/Homo sapiens IGKV1-33*01 (82.1%) -IGKJ4*01 (90.9%)), [6.3.9] (27'-32'.50'-52'.89'-97') (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')]; dimer (222-222'':225-225'')-bisdisulfide, produced in Chinese hamster ovary (CHO)/dhFr- cell line lacking the enzyme dihydrofolate reductase (DHFR), glycoform alfa

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