Гулгафафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2642374-02-3

humanized immunoglobulin G2-kappa, anti-(human glucagon- like peptide 1 receptor, GLP1R) (heavy chain 1-451, variant S³⁸²>A) fused at the N-terminus of each light chain (53-266) via the peptide linker ³⁰GSGSATGGSGSGASSGSGSATGS⁵² to a glucagon-like peptide-1 (GLP-1) fragment (7-35, 1-29 in the current sequence), variant (A²>G), disulfide bridged dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa;
humanized monoclonal antibody fusion with human Glucagon-like peptide 1 (GLP1); type: IgG2-kappa; antigen: human glucagon-like peptide 1 receptor, GLP-1 receptor, GLP-1-R, GLP-1R (GLP1R); CDR source: Mus musculus (humanized by Kabat CDR grafting); heavy chain class: gamma2; heavy chain length: 451; HV germline: Homo sapiens IGHV3-33*01; HJ germline: Homo sapiens IGHJ6*01; HC germline: Homo sapiens IGHG2*01; VH: 1-125; CH1: 126-223; hinge: 224-235; CH2: 236-344; CH3: 345-449 (S382A, non- functional mutation); CHS: 450-451; CDR Kabat H1: SYGMH (31- 35); CDR Kabat H2: VIWYDGSNKYYADSVKG (50-66); CDR Kabat H3: GGGSGSYRYYYYGLDV (99-114); fusion protein: 1-29 (human 7-35 glucagon-like peptide-1); linker: 30-52; light chain class: kappa; light chain length: 266; LV germline: Homo sapiens IGKV1-12*01; LJ germline: Homo sapiens IGKJ1*01; LC germline: Homo sapiens IGKC*01; VL: 53-159; CL: 160-266; CDR Kabat L1: RASQNINNLLA (76-86); CDR Kabat L2: TASSLQS (102-108); CDR Kabat L3: QQAHRFPPT (141-149)

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