Гумокимаб
GumokimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2428381-52-4
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens IL17A (interleukin 17A, IL-17A)], monoclonal antibody;
gamma1 heavy chain (1-450) [VH (Homo sapiens IGHV4-30-4*01 (90.8%) -(IGHD) -IGHJ4*01 (92.3%) L123>S (115), CDR-IMGT [9.7.13] (26-34.52-58.97-109)) (1-120) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-218')-disulfide with kappa light chain (1'-218') [V-KAPPA Musmus/Homsap (Mus musculus IGKV1-110*01 (94.9%) -IGKJ1*01 (100%)/Homo sapiens IGKV2-30*02 (88.0%) -IGKJ4*01 (90.9%) V124>L (108), CDR-IMGT [11.3.8] (27-37.55-57.94-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
gamma1 heavy chain (1-450) [VH (Homo sapiens IGHV4-30-4*01 (90.8%) -(IGHD) -IGHJ4*01 (92.3%) L123>S (115), CDR-IMGT [9.7.13] (26-34.52-58.97-109)) (1-120) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-218')-disulfide with kappa light chain (1'-218') [V-KAPPA Musmus/Homsap (Mus musculus IGKV1-110*01 (94.9%) -IGKJ1*01 (100%)/Homo sapiens IGKV2-30*02 (88.0%) -IGKJ4*01 (90.9%) V124>L (108), CDR-IMGT [11.3.8] (27-37.55-57.94-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
Структура
Иностранные названия
- Gumokimabum (латинское)
- Gumokimab (английское)
- Gumokimab (немецкое)
- Gumokimab (французское)
- Gumokimab (испанское)
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