Ифинатамаб дерукстекан

Rec. INN (наименование, зарегистрированное ВОЗ)

2484870-92-8

immunoglobulin G1-kappa, anti-[Homo sapiens CD276 (B7H3, B7-H3, B7-related protein 2, B7RP2, B7RP-2, B7 homolog 3, B7 homologue 3)], humanized monoclonal antibody, conjugated to deruxtecan, comprising a linker and a camptothecin derivative;
gamma1 heavy chain humanized (1-452) [VH (Homo sapiens IGHV1-3*01 (83.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 (CH1 R120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 E12 (361), M14 (363) (346-450), CHS (451-452)) (123-452)], (225-213')-disulfide with kappa light chain humanized (1'-213') [V-KAPPA (Homo sapiens IGKV3D-11*02 (85.6%) -IGKJ1*01 (100%), CDR-IMGT [5.3.9] (27-31.49-51.88-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152), V101 (190) (107'-213')]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa, conjugated, on an average of 4 cysteinyl, each via a thioether bond, to deruxtecan, comprising a linker and a camptothecin derivative.

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