Илофотаза альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2387636-92-0

human intestinal-type alkaline phosphatase (IAP) variant (H²⁷⁹>L, L³²⁸>V, P⁴⁷⁸>L), engineered by substituting its crown domain (366-430) with the human placental-type alkaline phosphatase (placental alkaline phosphatase 1, PLAP-1) crown domain (364-428, 366-430 in the current sequence), C-terminal linked glycosylphosphatidylinositol anchor removed, dimer, glycosylated, produced in Chinese hamster ovary (CHO) cells;
human intestinal-type alkaline phosphatase (ALPI, intestinal alkaline phosphatase, IAP) variant [H²⁷⁹>L, L³²⁸>V, P⁴⁷⁸>L] (1-484) with its crown domain (65-peptide 366-430) being replaced by the human placental-type alkaline phosphatase (ALPP, alkaline phosphatase Regan isozyme, placental alkaline phosphatase 1, PLAP-1) crown domain (65-peptide 364-428) (366-430), dimer (481-481')- disulfide, without glycosylphosphatidylinositol (GPI) anchors at Asp-484 and Asp-484' (secretable, soluble enzyme), produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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