Имелцимент

Prop. INN (наименование, предложенное ВОЗ)

2845128-03-0

immunoglobulin (H-gamma4_L-kappa)_G4hCH2CH3, anti-[vixticibart, monoclonal antibody allosteric agonist of Homo sapiens NPR1 (atrial natriuretic peptide receptor 1)], Homo sapiens monoclonal antibody;
H-gamma4 heavy chain anti-vixticibart Homo sapiens (1-448) [VH (Homo sapiens IGHV3-30-5*03 (94.9%) -(IGHD) -IGHJ4*01 (92.9%) T122>I (115), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v8 CH3 R115, F116, P125 (CH1 (122-219), hinge 1-12 S10>P (229) (220-231), CH2 L92 (310) (232-341), CH3 H115>R (436), Y116>F (437), L125>P (446) (342-446), CHS (447-448)) (122-448)], (135-213')-disulfide with L-kappa light chain anti-vixticibart Homo sapiens (1'-213') [V-KAPPA (Homo sapiens IGKV1-5*03 (98.9%) -IGKJ1*01 (91.7%) Q120>P (99'), CDR-IMGT [6.3.8] (27'-32'.50'-52'.89'-96')) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152'), V101 (190') (107'-213')];
G4hCH2CH3 chain Homo sapiens (1''-229'') [Homo sapiens IGHG4*01 (100%), nG4m(a) CH2 L92, G4v5 h P10 (hinge 1-12 S10>P (10'') (1''-12''), CH2 L92 (310'') (13''-122''), CH3 (123''-227''), CHS (228''-229''))]; dimer (227-8'':230-11'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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