Имвотамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2573121-53-4

Immunoglobulin M-kappa cyclic pentamer bisdisulfide with a fused scFv -JCHAIN (joining chain of multimeric IgA and IgM) -ALB (albumin) chain, anti-[Homo sapiens MS4A1 (membrane-spanning 4-domains subfamily A member 1, CD20)] (decavalent) and anti-[Homo sapiens CD3E (CD3e, CD3 epsilon)] (monovalent), monoclonal antibody, bispecific;
mu heavy chain anti-MS4A1 (1-575) [VH (Homo sapiens IGHV5-51*01 (99.0%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHM*03 (CH1 (123-226), CH2 (227-338), CH3 (339-444), CH4 (445-555), CHS (556-575)) (123-575)], (136-219')-disulfide with kappa light chain anti-MS4A1 (1'-219') [V-KAPPA (Homo sapiens IGKV2-24*01 (98.0%) -IGKJ4*01 (100%), CDR-IMGT [11.3.9] (27-37.55-57.94-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (336-336'':413-413'')-bisdisulfide, 5 [mu_kappa]2 dimers forming a cyclic pentamer, disulfide 4 x (574''-574), and 1x (574''-271'''':325''''-574)-bisdisulfide with scFv-JCHAIN-ALB (1''''-993'''') [scFv heavy-kappa anti-CD3E (1''''-241'''') [VH Musmus/Homsap (Mus musculus IGHV1-4*01 (83.7%) -(IGHD) -IGHJ3*01 (92.9%) A128>S (120)/Homo sapiens IGHV1-46*04 (82.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1''''-120'''') -15-mer tris(tetraglycyl-seryl) linker (121''''-135'''') -V-KAPPA (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ4*01 (100%), CDR-IMGT [5.3.9] (162-166.184-186.223-231)) (136''''-241'''')] -15-mer tris(tetraglycyl-seryl) linker (242''''-256'''') -JCHAIN (257''''-393'''') -15-mer tris(tetraglycyl-seryl) linker (394''''-408'''') -Homo sapiens ALB (albumin) (409''''-993'''')], produced in Chinese hamster ovary (CHO) cells, derived from CHO-K1 cell line, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

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