Имзокитуг

Prop. INN (наименование, предложенное ВОЗ)

2883771-61-5

immunoglobulin G1-kappa, anti-[Homo sapiens CCR8 (C-C motif chemokine receptor 8, CKR-L1, CDw198)], humanized monoclonal antibody;
H-gamma1 heavy chain humanized (1-445) [VH (Homo sapiens IGHV1-2*06 (85.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 E12 (355), M14 (357) (340-444), CHS K2>del (445)) (117-445)], (219-219')-disulfide with L-kappa light chain humanized (1'-219') [V-KAPPA (Homo sapiens IGKV2D-29*01 (90.0%) -IGKJ2*01 (100%), CDR-IMGT [11.3.9] (27'-37'.55'-57'.94'-102')) (1'-112') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (158'), V101 (196')) (113'-219')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, lacking the glutamine synthetase (GS-KO) gene and a1,6-fucosyltransferase (FUT8-KO) gene, glycoform alfa

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