Инезетамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2568264-76-4

immunoglobulin G1-scFv_L-lambda2 dimer, anti-[Homo sapiens CD40 (tumor necrosis factor receptor superfamily member 5, TNFRSF5)] and anti-[Homo sapiens MSLN (mesothelin, pre-pro-megakaryocyte-potentiating factor, megakaryocyte-potentiating factor, MPF, CAK1)], Homo sapiens monoclonal antibody, tetravalent, bispecific;
G1-scFv fused chain Homo sapiens (1-698) [gamma1 heavy chain anti-CD40 Homo sapiens (1-448) [VH (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, G1v30 CH2 N84.4>G (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 R83>C (295), N84.4>G (300), V85>C (305) (234-343), CH3 E12 (359), M14 (361) (344-448), CHS>del)) (121-448)] -10-mer bis(tetraglycyl-seryl) linker (449-458) -scFv heavy-kappa anti-MSLN Homo sapiens (459-698) [VH (Homo sapiens IGHV3-11*01 (93.9%) G49>C -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.10] (484-491.509-516.555-564)) (459-575) -15-mer tris(tetraglycyl-seryl) linker (576-590) -V-KAPPA (Homo sapiens IGKV1-12*01 (93.7%) -IGKJ1*01 (90.9%) Q120>C (690), CDR-IMGT [6.3.9] (617-622.640-642.679-687)) (591-698)], (223-216')-disulfide with lambda2 light chain anti-CD40 Homo sapiens (1'-217') [V-LAMBDA (Homo sapiens IGLV2-14*01 (90.8%) -IGLJ2*01 (91.7%), CDR-IMGT [9.3.11] (26-34.52-54.91-101)) (1'-111') -Homo sapiens IGLC2*01 (100%) (112'-217')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, non-glycosylated

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