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USAN (наименование, принятое к употреблению в США)

Prop. INN (наименование, предложенное ВОЗ)

2839572-09-5

immunoglobulin (G1_L-kappa)_(G1-scFvkh_L-kappa), anti-[Homo sapiens TNFRSF17 (tumor necrosis factor (TNF) receptor superfamily member 17, B cell maturation antigen, BCMA, TNFRSF13A, CD269)], anti-[Homo sapiens KLRK1 (killer cell lectin like receptor K1, NKG2D, KLR, NKG2-D, CD314)], Homo sapiens monoclonal antibody, bispecific;
H-gamma1 heavy chain Homo sapiens, anti-TNFRSF17 (1-445) [VH (Homo sapiens IGHV3-23*01 (94.9%) -(IGHD) -IGHJ5*01 (93.3%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01 G1m17,1 CH1 K120, CH3 D12, L14, G1v75 CH3 C5, G1v90 CH3 E16, W88 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 Y5>C (348), D12 (355), L14 (357), K16>E (359), K88>W (408) (340-444), CHS K2>del (445)) (117-445)], (219-216’)-disulfide with common L-kappa light chain anti-TNFRSF17 Homo sapiens (1'-216') [V-KAPPA (Homo sapiens IGKV3-20*01 (90.6%) -IGKJ1*01 (91.7%), CDR-IMGT [7.3.10] (27'-33'.51'-53'.90'-99')) (1'-109') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (155'), V101 (193')) (110'-216')];
H-gamma1 heavy chain anti-TNFRSF17 fused to a scFv anti-KLRK1 (1''-702'') [ H-gamma1 heavy chain anti-TNFRSF17 Homo sapiens (1''-445'') [VH (Homo sapiens IGHV3-23*01 (94.9%) -(IGHD) -IGHJ5*01 (93.3%), CDR-IMGT [8.8.9] (26''-33''.51''-58''.97''-105'')) (1''-116'') -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v74 CH3 C10, G1v91 CH3 R3, V84.2, T85.1 (CH1 K120 (213'') (117''-214''), hinge 1-15 (215''-229''), CH2 (230''-339''), CH3 Q3>R (346''), S10>C (353''), D12 (355''), L14 (357''), D84.2>V (398''), F85.1>T (404'') (340''-444''), CHS K2>del (445'')) (117''-445'')] -8-mer (seryl-glycyl-seryl-tetraglycyl-seryl) linker (446''-453'') -scFvkh anti-KLRK1 Homo sapiens (454''-702'') [V-KAPPA (Homo sapiens IGKV1-12*01 (97.9%) -IGKJ1*01 (90.9%) Q120>C (553''), CDR-IMGT [6.3.9] (480''-485''.503''-505''.542''-550'')) (454''-560'') -20-mer tetrakis(tetraglycyl-seryl) linker (561''-580'') -VH (Homo sapiens IGHV3-21*01 (99.0%) -IGHD -IGHJ5*02 (100%), CDR-IMGT [8.8.15] (606''-613''.631''-638''.677''-691'')) (581''-702'')]]; (219''-216''')-disulfide with common L-kappa light chain anti-TNFRSF17 Homo sapiens (1'''-216''') [V-KAPPA (Homo sapiens IGKV3-20*01 (90.6%) -IGKJ1*01 (91.7%), CDR-IMGT [7.3.10] (27'''-33'''.51'''-53'''.90'''-99''')) (1'''-109''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (155'''), V101 (193''')) (110'''-216''')];
dimer (225-225'':228-228'':348-353'')-trisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa

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