Интисмеран аутоген

Prop. INN (наименование, предложенное ВОЗ)

2931460-85-2

messenger RNA (mRNA), 5'-capped, encoding a codon-optimized patient specific concatemer of up to 34 neoantigens designed specifically to each individual patient's tumor mutanome and human leukocyte antigen (HLA) type, further optimized by two additional stop codons, flanked by an artificial 5' untranslated region (UTR) and a 3' UTR derived from the human hemoglobin subunit alpha (HBA1) gene and terminated by a 3' polyadenylation (polyA) tail; contains N¹-methylpseudouridine instead of uridine (all-U>m1Ψ)

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