Инвикафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2894138-60-2

humanized immunoglobulin G1-kappa anti-(human T cell receptor germline-encoded variable chain Vβ6/β10) monomer disulfide bridged to human interleukin 2 (IL-2, T-cell growth factor) fragment fused via (G4S)2 peptide linker to immunoglobulin G1 Fc fragment, glycoform alfa;
gamma 1 heavy chain (1-447) [VH (Homo sapiens IGHV1-3*01 -(IGHD) - IGHJ4*01, CDR-Kabat [5.17.10] (31-35.50-66.99-108)) (1-119) -Homo sapiens IGHG1*03 (CH1 (120-217), hinge (218-232), CH2 N²⁹⁹>A (233- 342), CH3 Y³⁵¹>C, T³⁶⁸>S, L³⁷⁰>A, Y⁴⁰⁹>V (343-447), CHS G⁴⁴⁸>del, K⁴⁴⁹>del) (120-447)], (222-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-9*01 -IGKJ2*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')];
(228-149'':231:152'': 351:277'')-trisdisulfide with human interleukin 2 (IL-2, T-cell growth factor) fragment 21-153 (1-133 in the current sequence) fused via (G4S)2 peptide linker (134-143) to a Fc fragment of human immunoglobulin G1 (144-368) [Homo sapiens IGHG1*03, hinge N- terminal EPKSC deleted (144-153), CH2 N²²⁰>A (154-263), CH3 S²⁷⁷>C, T²⁸⁹>W (264-368), CHS G³⁶⁹>del, K³⁷⁰>del]; produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1 cells, glycoform alfa

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