Инвимэстроцел

Rec. INN (наименование, зарегистрированное ВОЗ)

Allogeneic human multipotent adult progenitor cells (MAPC) derived from bone marrow and isolated by density gradient centrifugation. The cells are expanded ex vivo on fibronectin-coated surfaces under lowoxygen conditions and in the presence of growth media for the creation of a master cell bank (passage 4), a working cell bank (passage 6) and active substance (passage 9). The cells are adherent, secrete proangiogenic factors (including VEGF, IL-8 and CXCL5) and of mesenchymal progenitor lineage (in vitro differentiation to endothelial, hepatic and neuronal lineages). The cells express CD49c and CD90 (≥ 95% of the cells), and lack expression of CD45 and HLA II (< 5%). Additional markers include > 90% CD13, CD44, CD73, CD105 and < 5% CD34. The cells have also been shown to induce T cell suppression.

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