Ипаромлимаб
IparomlimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2417649-33-1
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)], humanized and chimeric monoclonal antibody;
gamma4 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-46*01 (85.7%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (120-217), hinge 1-12 S10>P (227) (218-229), CH2 (230-339), CH3 (340-444), CHS (445-446)) (120-446)], (133-220')-disulfide with kappa light chain chimeric (1'-220') [V-KAPPA Musmus/Homsap (Mus musculus IGKV8-28*01 (82.2%) -IGKJ2*01 (91.7%) L124>V (110)/Homo sapiens IGKV1-27*01 (80.2%) -IGKJ4*01 (100%), CDR-IMGT [12.3.9] (27-38.56-58.95-103)) (1'-113') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (159), V101 (197) (114'-220')]; dimer (225-225'':228-228'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-S cell line, glycoform alfa
gamma4 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-46*01 (85.7%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (120-217), hinge 1-12 S10>P (227) (218-229), CH2 (230-339), CH3 (340-444), CHS (445-446)) (120-446)], (133-220')-disulfide with kappa light chain chimeric (1'-220') [V-KAPPA Musmus/Homsap (Mus musculus IGKV8-28*01 (82.2%) -IGKJ2*01 (91.7%) L124>V (110)/Homo sapiens IGKV1-27*01 (80.2%) -IGKJ4*01 (100%), CDR-IMGT [12.3.9] (27-38.56-58.95-103)) (1'-113') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (159), V101 (197) (114'-220')]; dimer (225-225'':228-228'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-S cell line, glycoform alfa
Структура
Иностранные названия
- Iparomlimabum (латинское)
- Iparomlimab (английское)
- Iparomlimab (немецкое)
- Iparomlimab (французское)
- Iparomlimab (испанское)
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