Испектамаб тазид

Rec. INN (наименование, зарегистрированное ВОЗ)

2585651-78-9

immunoglobulin G1-kappa [186,410-bis[4-(azidomethyl)-L-phenylalanine]], anti-[Homo sapiens TNFRSF17 (TNF receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, B cell maturation antigen, BCMA, BCM, TNFRSF13A, CD269)], humanized monoclonal antibody;
l-methionyl (1)-gamma1 heavy chain humanized (1-453) [VH (Homo sapiens IGHV3-66*01 (82.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.15] (27-34.52-59.98-112)) (1-123) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 Y85.2>F (pAMF) (186), R120>K (220) (124-221), hinge 1-15 (222-236), CH2 (237-346), CH3 E12 (362), M14 (364), F85.2>F (pAMF) (410) (347-451), CHS (452-453)) (124-453)], (226-215')-disulfide with l-methionyl (1')-kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV1-39*01 (84.2%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (28-33.51-53.90-98)) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (232-232'':235-235")-bisdisulfide, produced by a cell-free protein expression system based on Escherichia coli lysate, non-glycosylated, conjugated at C-4 of the four l-phenylalanyl residues 186, 410, 186'' and 410'' with azidomethyl (tazide) groups by genetically predetermined incorporation of 4-(azidomethyl)-l-phenylalanyl residues in these specific positions

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