Истиратумаб

C₈₈₀₂H₁₃₅₃₂N₂₃₉₂O₂₇₉₆S₅₈

• Молярная масса: 199458,51 г/моль
• Химическое название: immunoglobulin G1-kappa anti-[Homo sapiens IGF1R (insulin-like growth factor 1 receptor, IGF1-R, IGF-1R, CD221)], each heavy chain being fused to a scFv anti-[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)], Homo sapiens monoclonal antibody, bispecific tetravalent;
  gamma1 heavy chain anti-IGFR1 fused to a scFv anti-ERBB3 (1-720) [Homo sapiens gamma1 heavy chain {(Homo sapiens VH (IGHV3-23*01 (90.80%) -(IGHD) -IGHJ4*01 L123>T (117)) [8.8.15] (1-122) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (219) (123-220), hinge (221-235), CH2 (236-345), CH3 E12 (361), M14 (363) (346-450), CHS K2>del (451)) (123-451)} (1-451)-15-mer tris(tetraglycyl-seryl) linker (452-466) -scFv {(Homo sapiens VH (IGHV3-9*01 (92.90%) -(IGHD) -IGHJ4*01) [8.8.15] (467-588) -23-mer alanyl-seryl-threonyl-tetrakis(tetraglycyl-seryl) linker (589-611) -Homo sapiens V-LAMBDA (IGLV3-19*01 (94.80%) -IGLJ3*02 L124>V (716)) [6.3.11] (612-719) -glycyl (720)} (467-720)], (225-214')-disulfide with kappa light chain anti-IGFR1 (1'-214') [Homo sapiens V-KAPPA (IGKV1-12*01 (90.50%) -IGKJ4*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (231-231'':234-234'')-bisdisulfide
• Drugbank: DB15363
• CAS: 1509928-04-4
• Структура

Информация о действующем веществе Истиратумаб предназначена для медицинских и фармацевтических специалистов, исключительно в справочных целях.