Итанистомиг

Prop. INN (наименование, предложенное ВОЗ)

2923687-56-1

immunoglobulin (VH-G1CH1-h)-H-gamma1_L-kappa-L-kappa, anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)] and anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3)], Homo sapiens and humanized monoclonal antibody, bispecific, tetravalent;
fused heavy chain (VH anti-CD274 -G1CH1-h)-H-gamma1 anti-CD47 (1-683) [(VH-G1CH1-h) chain anti-CD274, Homo sapiens (1-226) [(VH (Homo sapiens IGHV1-69*01 (93.9%) -(IGHD) -IGHJ6*01 (93.8%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*01 CH1-h, G1m17,1 CH1 K120 (CH1 K120 (220) (124-221), hinge 1-5 (222-226) (124-226))] -11-mer (GPAPELL-trisglycyl-seryl) linker (227-237) -H-gamma1 anti-CD47, humanized (238-683) [VH (Homo sapiens IGHV5-51*01 (89.8%) -IGHD -IGHJ1*01 (100%), CDR-IMGT [8.8.9] (263-270.288-295.334-342)) (238-353) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (450) (354-451), hinge 1-15 (452-466), CH2 (467-576), CH3 D12 (592), L14 (594) (577-681), CHS (682-683)) (354-683)]], dimer (226-213':456-443')-bisdisulfide with fused light chain L-kappa anti-CD274-L-kappa anti-CD47 (1’-443’) [L-kappa anti-CD274, Homo sapiens (1’-213’) [V-KAPPA (Homo sapiens IGKV3-11*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [6.3.8] (27’-32’.50’-52’.89’-96’)) (1’-106’) -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (152’), V101 (190')) (107’-213’)] -11-mer (GPAPLGL-trisglycyl-seryl) linker (214’-224’) -L-kappa anti-CD47, humanized (225’-443’) [V-KAPPA (Homo sapiens IGKV2-28*01 (92.0%) -IGKJ4*01 (100%), CDR-IMGT [11.3.9] (251’-261’.279’-281’.318’-326’)) (225’-336’) -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (382’), V101 (420')) (337’-443’)]]; dimer (462-462'':465-465'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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