Ивицентамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2364496-42-2

immunoglobulin G1-kappa, anti-[Homo sapiens CD37 (tetraspanin-26, TSPAN26)], humanized monoclonal antibody, biparatopic;
gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-66*01 (85.6%) -(IGHD) -IGHJ2*01 (86.7%) R120>Q (112), CDR-IMGT [8.7.14] (26-33.51-57.96-109)) (1-120) -Homo sapiens IGHG1*03, G1m3, nG1m1 (CH1 R120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361), F85.1>L (408), E109>G (433) (344-448), CHS K2>del (449)) (121-449)], (223-217')-disulfide with kappa light chain humanized (1'-217') [V-KAPPA (Homo sapiens IGKV1-5*03 (86.5%) -IGKJ4*01 (100%), CDR-IMGT [6.3.12] (27-32.50-52.89-100)) (1'-110') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (156), V101 (194) (111'-217')];
gamma1 heavy chain humanized (1''-448'') [VH (Homo sapiens IGHV3-66*01 (85.6%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1''-119'') -Homo sapiens IGHG1*03, G1m3, nG1m1 (CH1 R120 (216) (120''-217''), hinge 1-15 (218''-232''), CH2 (233''-342''), CH3 E12 (358), M14 (360), K88>R (411), E109>G (432) (343''-447''), CHS K2>del (448)) (120''-448'')], (222''-217''')-disulfide with kappa light chain humanized (1'''-217''') [V-KAPPA (Homo sapiens IGKV1-9*01 (87.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.12] (27-32.50-52.89-100)) (1'''-110''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (156), V101 (194) (111'''-217''')]; dimer (229-228'':232-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

Поделиться этой страницей