Ивонескимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2428381-53-5

immunoglobulin G1-kappa_scFv, anti-[Homo sapiens VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF)], each heavy chain being fused to a scFv anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)], monoclonal antibody, tetravalent, bispecific;
gamma1 heavy chain anti-VEGFA fused to scFv anti-PDCD1 (1-719) [gamma1 heavy chain anti-VEGFA (1-453) [VH (Homo sapiens IGHV3-30*02 (76.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (220) (124-221), hinge 1-15 (222-236), CH2 L1.3>A (240), L1.2>A (241) (237-346), CH3 D12 (362), L14 (364) (347-451), CHS (452-453)) (124-453)] -20-mer tetrakis(tetraglycyl-seryl) linker (454-473) -scFv-VH-V-KAPPA anti-PDCD1 (474-719) [VH (Homo sapiens IGHV3-23*04 (88.7%) -(IGHD) -IGHJ6*01 (90.9%) T123>L (586), CDR-IMGT [8.8.11] (499-506.524-531.570-580)) (474-591) -20-mer tetrakis(tetraglycyl-seryl) linker (592-611) -V-KAPPA Musmus/Homsap (Mus musculus IGKV14-111*01 (86.3%) -IGKJ5*01 (100%)/Homo sapiens IGKV1-16*01 (80.0%) -IGKJ2*01 (87.5%) Q120>A (711), CDR-IMGT [6.3.9] (638-643.661-663.700-708)) (612-719)], (226-214')-disulfide with kappa light chain anti-VEGFA (1'-214') [V-KAPPA (Homo sapiens IGKV1-16*01 (88.4%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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