Изалонтамаб бренгитекан

Rec. INN (наименование, зарегистрированное ВОЗ)

2760528-47-8

immunoglobulin G1-scFv_L-kappa dimer, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)] and anti-[Homo sapiens ERBB3 (receptor tyrosineprotein kinase erbB-3, HER3)], chimeric and Homo sapiens monoclonal antibody, tetravalent, bispecific, conjugated to a camptothecin derivative;
fused G1-scFv heavy-lambda heavy chain chimeric and Homo sapiens (1-702) [gamma1 heavy chain anti-EGFR chimeric (1-448) [VH (Mus musculus IGHV2-2*03 (93.8%) -(IGHD) -IGHJ3*01 (92.9%) A128>S (119), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*08p (100%), G1m3,1 (CH1 I103 (201), R120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 D12 (358), L14 (360) (343-447), CHS K2>del (448)) (120-448)] -10-mer bis(tetraglycyl-seryl) linker (449-458) -scFv heavy-lambda anti-ERBB3 Homo sapiens (459-702) [VH (Homo sapiens IGHV3-7*01 (91.8%) -(IGHD) -IGHJ2*01 (100%), CDR-IMGT [8.8.11] (484-491.509-516.555-565)) (459-576) -15-mer tris(tetraglycyl-seryl) linker (577-591) -V-LAMBDA (Homo sapiens IGLV2-14*03 (93.9%) -IGLJ2*01 (83.3%) L124>V (699), CDR-IMGT [9.3.11] (617-625.643-645.682-692)) (592-702)]], (222-214')-disulfide with kappa light chain anti-EGFR chimeric (1'-214') [V-KAPPA (Mus musculus IGKV5-48*01 (95.8%) -IGKJ5*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; substituted at the sulfur atoms of the l-cysteinyl residues 214', 214''', 222, 222'', 228, 228'', 231, 231'' with group (3RS)-1-[(4S,13S,21S)-13-benzyl-1-carboxy-22-{[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino}-21-methyl-5,8,11,14,17,22-hexaoxo-20-oxa-2,6,9,12,15,18-hexaazadocosan-4-yl]-2,5-dioxopyrrolidin-3-yl

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