Изелтабарт тапатансин

Rec. INN (наименование, зарегистрированное ВОЗ)

2642078-62-2

immunoglobulin G1-kappa, anti-[Homo sapiens ADAM9 (ADAM metallopeptidase domain 9, cone rod dystrophy 9, CORD9, meltrin gamma, MDC9, MCMP)], humanized monoclonal antibody, conjugated with the tubulin inhibitor N^2'-deacetylmaytansine via a 6-(6-maleimidohexanoyl-l-alanyl-d-alanyl-l-alaninamidomethylthio)hexanoyl linker at two engineered cysteine sites 448 and 448'';
gamma1 heavy chain humanized (1-452) [VH humanized (Homo sapiens IGHV3-64*07 (81.6%) -(IGHD) -IGHJ4*01 (80%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*03, G1m3, nG1m1, G1v21 CH2 Y15.1, T16, E18, G1v44 CH3 C122 (CH1 R120 (220) (124-221), hinge 1-15 (222-236), CH2 M>Y15.1 (258), S>T16 (260), T>E18 (262) (237-346), CH3 E12 (362), M14 (364), S>C122 (448) (347-451), CHS K2>del (452)) (124-452)], (226-218')-disulfide with kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV4-1*01 (77.2%) -IGKJ2*02 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01, Km3, A45.1 (157), V101 (195) (112'-218')]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa; substituted at the sulfur atoms of the l-cysteinyl residues 448 and 448'' with two (3RS)-1-[(2S,14S,17R,20S)-1-{[(1⁴S,1⁶S,2R,3²S,3³S,4S,10E,12E,14R)-8⁶-chloro-1⁴-hydroxy-8⁵,14-dimethoxy-2,3³,7,10-tetramethyl-1²,6-dioxo-7-aza-1(6,4)-[1,3]oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl]oxy}-2,3,14,17,20-pentamethyl-1,4,13,16,19,22-hexaoxo-10-thia-3,12,15,18,21-pentaazaheptacosan-27-yl]-2,5-dioxopyrrolidin-3-yl (tapatansine) groups

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