Изениветмаб
IzenivetmabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2447755-72-6
Химическое название
immunoglobulin G2-kappa, anti-[Canis lupus familiaris NGF (nerve growth factor beta polypeptide, NGFB)], caninized monoclonal antibody;
gamma2 heavy chain caninized (1-453) [VH (Canis lupus familiaris IGHV3-67*01 (82.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Canis lupus familiaris IGHG2*02 (CH1 (119-215), hinge 1-19 (216-234), CH2 M1.3>A (238), L1.2>A (239), G1>A (241) (235-344), CH3 (345-451), CHS (452-453)) (119-453)], (133-213')-disulfide with kappa light chain caninized (1'-213') [V-KAPPA (Canis lupus familiaris IGKV3-18*02 (85.7%) -IGKJ3*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Canis lupus familiaris IGKC*01 (100%) (108'-213')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
gamma2 heavy chain caninized (1-453) [VH (Canis lupus familiaris IGHV3-67*01 (82.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Canis lupus familiaris IGHG2*02 (CH1 (119-215), hinge 1-19 (216-234), CH2 M1.3>A (238), L1.2>A (239), G1>A (241) (235-344), CH3 (345-451), CHS (452-453)) (119-453)], (133-213')-disulfide with kappa light chain caninized (1'-213') [V-KAPPA (Canis lupus familiaris IGKV3-18*02 (85.7%) -IGKJ3*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Canis lupus familiaris IGKC*01 (100%) (108'-213')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
Структура
Иностранные названия
- Izenivetmabum (латинское)
- Izenivetmab (английское)
- Izenivetmab (немецкое)
- Izenivetmab (французское)
- Izenivetmab (испанское)
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