Изуралимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2329669-80-7

immunoglobulin half-IG G1-kappa/scFv-h-CH2-CH3, anti-[Homo sapiens ICOS (inductible T-cell costimulatory, activation-inducible lymphocyte immunomediatory molecule, AILIM, CD278)] and anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], monoclonal antibody, bispecific;
gamma1 heavy chain anti-ICOS (1-454) [VH (Homo sapiens IGHV1-2*02 (99%) -(IGHD) -IGHJ3*02 (100%)) CDR-IMGT [8.8.18] (26-33.51-58.97-114) (1-125) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 N114>D (216) R120>K (222) (126-223), hinge 1-15 (224-238), CH2 E1.4,L1.3>P (241), L1.2>V (242), G1.1>A (243), S29>K (274), Q84.2>E (302) (239-347), CH3 E12 (363), M14 (365), L24>D (375), K26>S (377), N44>D (391), Q97>E (425), N100>D (428), M107>L (435), N114>S (441) (348-452), CHS (453-454)) (126-454)], (228-214')-disulfide with kappa light chain anti-ICOS (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (96.8%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)];
IG scFv-h-CH2-CH3 single chain, anti-PDCD1 (1''-480'') [scFv-V-kappa-VH anti-PDCD1 (1''-249'') [V-KAPPA (Homo sapiens IGKV3-15*01 (80.0%) -IGKJ4*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1''-107'') -20-mer tetrakis(glycyl-lysyl-prolyl-glycyl-seryl) linker (108''-127'') -VH (Mus musculus IGHV6-6*02 (87.0%) -(IGHD) -IGHJ1*03 (86.7%)/Homo sapiens IGHV3-15*07 (81.8%) -(IGHD) -IGHJ2*01 (93.3%)) CDR-IMGT [8.10.13] (153-160.178-187.226-238) (128''-249'')] -Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 (250''-480'') [hinge 1-15 C5>S (254) (250-264) -CH2 E1.4,L1.3>P (267), L1.2>V (268), G1.1>A (269), S29>K (300) (265-373),CH3 E12 (389), E13>Q (390), M14 (391), S20>K (397), M107>L (461), N114>S (467) (374-478), CHS (479-480)]];
dimer (234-260'':237-263'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-S cell line, glycoform alfa

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