Ладиратузумаб ведотин

Ladiratuzumab vedotin

МНН

Rec. INN (наименование, зарегистрированное ВОЗ)

Drugbank

DB15409

CAS

1629760-29-7

Химическое название

immunoglobulin G1-kappa, anti-[Homo sapiens SLC39A6 (solute carrier family 39 member 6, solute carrier family 39 (metal ion transporter) member 6, solute carrier family 39 (zinc transporter) member 6, LIV-1)], humanized monoclonal antibody conjugated to auristatin E;
gamma1 heavy chain (1-450) [humanized VH (Homo sapiens IGHV1-2*02 (87.60%) -(IGHD) -IGHJ4*01) [8.8.13] (1-120) -Homo sapiens IGHG1*01, G1m17,1 (CH1 K120 (217) (121-218), hinge (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-219')-disulfide with kappa light chain (1’-219’) [humanized V-KAPPA (Homo sapiens IGKV2-30*02 (89.00%) -IGKJ4*01) [11.3.9] (1'-112') -Homo sapiens IGKC*01, Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (229-229":232-232")-bisdisulfide; conjugated, on an average of 4 cysteinyl, to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker

Структура

Иностранные названия

Ladiratuzumabum vedotinum (латинское)
Ladiratuzumab vedotin (английское)
Ladiratuzumab védotine (французское)
Ladiratuzumab vedotina (испанское)

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