Лапритуксимаб эмтансин
Laprituximab emtansineМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
1622327-37-0
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)], chimeric monoclonal antibody conjugated to maytansinoid DM1;
gamma1 heavy chain (1-448) [Mus musculus VH (IGHV1- 7*01 -(IGHD)-IGHJ4*01) [8.8.12] (1-119) -Homo sapiens IGHG1*01, Gm17,1 (CH1 (120-217), hinge (218-232), CH2 (233-342), CH3 (343-447), CHS K2>del (448) (120-448)], (222-214')-disulfide with kappa light chain (1'-214') [Mus musculus V-KAPPA (IGKV19-93*01-IGKJ2*03) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide; conjugated, on an average of 3 to 4 lysyl, to maytansinoid DM1 via a succinimidyl-4-(N-maleimidomethyl) cyclohexane1-carboxylate (SMCC) linker forming a nonreducible thioether bond
gamma1 heavy chain (1-448) [Mus musculus VH (IGHV1- 7*01 -(IGHD)-IGHJ4*01) [8.8.12] (1-119) -Homo sapiens IGHG1*01, Gm17,1 (CH1 (120-217), hinge (218-232), CH2 (233-342), CH3 (343-447), CHS K2>del (448) (120-448)], (222-214')-disulfide with kappa light chain (1'-214') [Mus musculus V-KAPPA (IGKV19-93*01-IGKJ2*03) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide; conjugated, on an average of 3 to 4 lysyl, to maytansinoid DM1 via a succinimidyl-4-(N-maleimidomethyl) cyclohexane1-carboxylate (SMCC) linker forming a nonreducible thioether bond
Структура
Иностранные названия
- Laprituximabum emtansinum (латинское)
- Laprituximab emtansine (английское)
- Laprituximab emtansin (немецкое)
- Laprituximab emtansine (французское)
- Laprituximab emtansina (испанское)
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