Ларнефпендекин альфа
Larnefpendekin alfaМНН
Prop. INN (наименование, предложенное ВОЗ)
CAS
2877653-03-5
Химическое название
human interleukin-15 (IL-15) fused via a peptide linker to human immunoglobulin G1 constant heavy chain, disulfide-bridged to human immunoglobulin kappa constant light chain fused via a peptide linker to human interleukin-15 receptor subunit alpha (IL-15R-alpha, IL-15RA, CD215);
human interleukin-15 (IL-15) (1-114, 2-115 in the current sequence, D1>added, variant (N72>D73) fused via peptide linker 116AGGKPGGSAGG126 to gamma 1 heavy chain (127-454) [Homo sapiens IGHG1*08 (CH1 (127-224), hinge (225-239), CH2 L243>A, L244>A (240-349), CH3 (350-454), CHS G455>del, K456>del)], (229- 216')-disulfide with kappa light chain (110'-216') [Homo sapiens IGKC*01] fused via peptide linker 104'GAEGGG109' to human interleukin-15 receptor subunit alpha (IL-15R-alpha, IL-15RA, CD215) (1'-103', variant I1'>D), dimer (235-235'':238-238'')- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa
human interleukin-15 (IL-15) (1-114, 2-115 in the current sequence, D1>added, variant (N72>D73) fused via peptide linker 116AGGKPGGSAGG126 to gamma 1 heavy chain (127-454) [Homo sapiens IGHG1*08 (CH1 (127-224), hinge (225-239), CH2 L243>A, L244>A (240-349), CH3 (350-454), CHS G455>del, K456>del)], (229- 216')-disulfide with kappa light chain (110'-216') [Homo sapiens IGKC*01] fused via peptide linker 104'GAEGGG109' to human interleukin-15 receptor subunit alpha (IL-15R-alpha, IL-15RA, CD215) (1'-103', variant I1'>D), dimer (235-235'':238-238'')- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa
Структура
Иностранные названия
- Larnefpendekinum alfa (латинское)
- Larnefpendekin alfa (английское)
- Larnefpendekin alfa (немецкое)
- Larnefpendékine alfa (французское)
- Larnefpendekina alfa (испанское)
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