Ларнефпендекин альфа

Prop. INN (наименование, предложенное ВОЗ)

2877653-03-5

human interleukin-15 (IL-15) fused via a peptide linker to human immunoglobulin G1 constant heavy chain, disulfide-bridged to human immunoglobulin kappa constant light chain fused via a peptide linker to human interleukin-15 receptor subunit alpha (IL-15R-alpha, IL-15RA, CD215);
human interleukin-15 (IL-15) (1-114, 2-115 in the current sequence, D¹>added, variant (N⁷²>D⁷³) fused via peptide linker ¹¹⁶AGGKPGGSAGG¹²⁶ to gamma 1 heavy chain (127-454) [Homo sapiens IGHG1*08 (CH1 (127-224), hinge (225-239), CH2 L²⁴³>A, L²⁴⁴>A (240-349), CH3 (350-454), CHS G⁴⁵⁵>del, K⁴⁵⁶>del)], (229- 216')-disulfide with kappa light chain (110'-216') [Homo sapiens IGKC*01] fused via peptide linker ¹⁰⁴'GAEGGG¹⁰⁹' to human interleukin-15 receptor subunit alpha (IL-15R-alpha, IL-15RA, CD215) (1'-103', variant I1'>D), dimer (235-235'':238-238'')- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa

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