Латикафусп

Rec. INN (наименование, зарегистрированное ВОЗ)

2552814-07-8

human immunoglobulin G1-lambda, anti-(human programmed cell death protein 1), with one gammal heavy chain (1-450, variant R>C²⁹⁶, N>G³⁰¹,V>C³⁰⁶, E>K³⁶⁰, D>K⁴⁰³, C-terminal K⁴⁵¹ deleted) fused at the C-terminus to a human interleukin 21 fragment (1-133, 451-583 in the current sequence) variant (R⁹>E⁴⁵⁹, R⁷⁶>A⁵²⁶), disulfide bridged to gamma1 heavy chain (1-451, variant R>C²⁹⁶, N>G³⁰¹,V>C³⁰⁶, K>D³⁹⁶, K>D⁴¹³), with each gamma1 chain disulfide bridged to the same lambda light chain, non­glycosylated, produced in Chinese hamster ovary (CHO) cells;
immunoglobulin G1-lambda, anti-[Homo sapiens PDCD1 (programmed cell death protein 1, PD1, PD-1, CD279)], Homo sapiens monoclonal antibody derived from a transgenic mouse, fused at the C-terminus of one of the heavy chains to a human interleukin 21 fragment; gamma1 heavy chain Homo sapiens (1-451) [VH (Homo sapiens IGHV3-20*04 (90.8%) -(IGHD) -IGHJ5*02 (100%), CDR- Kabat [5.17.12] (31-35.50-66.99-110)), (1-121) -Homo sapiens IGHG1*03 (CH1 R²¹⁸>K (122-219), hinge (220­234), CH2 R²⁹⁶>C, N³⁰¹>G, V³⁰⁶>C (235-344), CH3 E³⁶⁰>K, D⁴⁰³>K (345-449), CHS K⁴⁵¹>del (450)) (122-450)], fused to interleukin-21 (IL-21) (451-583) [R⁹>E⁴⁵⁹, R⁷⁶>A⁵²⁶]-mutant, (224-213')-disulfide with lambda light chain Homo sapiens (1'-214') [V-LAMBDA (Homo sapiens IGLV3-10*01 (95.8%) -IGLJ2*01 (100%), CDR-Kabat [11.7.11] (23-33.49-55.88­98)) (1'-108') -Homo sapiens IGLC2*01 (100%) (109'-214')]; gamma1 heavy chain Homo sapiens (1''-451'') [VH (Homo sapiens IGHV3-20*04 (90.8%) -(IGHD) -IGHJ5*02 (100%), Homo sapiens (1''-451'') [VH (Homo sapiens IGHV3-20*04 (90.8%) - (IGHD) -IGHJ5*02 (100%), CDR-Kabat [5.17.12] (31-35.50-66.99-110)) (1''-121'') -Homo sapiens IGHG1*03 (CH1 R²¹⁸>K (122''-219''), hinge (220''-234''), CH2 R²⁹⁶>C, N³⁰¹>G, V³⁰⁶>C (235''-344''), CH3 K³⁹⁶>D, K⁴¹³>D (345''-449''), CHS (450''-451'')) (122''-451'')], (224''-213''')-disulfide with lambda light chain Homo sapiens (i'"-214'") [V-LAMBDA (Homo sapiens IGLV3-10*01 (95.8%) -IGLJ2*01 (100%) CDR-Kabat [11.7.11] (23-33.49-55.88-98)) (1'''-108''') -Homo sapiens IGLC2*01 (100%) (109'''­214''')]; (230-230'':233-233'')-bisdisulfide, non-glycosylated, produced in Chinese hamster ovary (CHO) cells

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