Латоветцел

Rec. INN (наименование, зарегистрированное ВОЗ)

equine allogeneic mesenchymal stem/stromal cells (MSCs) isolated from peripheral blood mononuclear cells (PBMCs) collected from donor horses. The MSCs are selected for by growing the PBMCs in media containing fetal bovine serum (FBS) and dexamethasone and then further expanded in media containing FBS.
The final cells are characterized by their stretched spindle shaped morphology, and by expression of the cellular surface markers CD90 (≥95%) and CD40 (≥85%) and absence of MHC class II expression (≤2%). The cells secrete prostaglandin E2 (PGE2) and interleukin 6 (IL-6) and can decrease proliferation (>85%) in a mixed lymphocyte reaction assay with concanavalin A (ConA)-stimulated canine PMBCs

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