Латозинемаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2376132-27-1

immunoglobulin G1-kappa, anti-[Homo sapiens SORT1 (sortilin 1, Gp95, NT3)], Homo sapiens monoclonal antibody;
gamma1 heavy chain Homo sapiens (1-452) [VH (Homo sapiens IGHV4-38-2*01 (99.0%) -(IGHD) -IGHJ6*01 (100%)) CDR-IMGT [9.7.15] (26-34.52-58.97-111) (1-122) -Homo sapiens IGHG1*01 G1m17,1, G1v40 CH2 A1.3, A1.2, S116 (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 L1.3>A (239), L1.2>A (240), P116>S (336) (236-345), CH3 D12 (361), L14 (363) (346-450), CHS (451-452)) (123-452)], (225-219')-disulfide with kappa light chain Homo sapiens (1'-219') [V-KAPPA (Homo sapiens IGKV2-28*01 (93.0%) -IGKJ4*01 (100%)) CDR-IMGT [11.3.9] (27-37.55-57.94-102) (1'-112') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (231-231'':234-234'')-bisdisulfide, produced in a glutamine synthetase-Chinese hamster ovary (CHO) cell based expression system, GSKO CHOK1SV, glycoform alfa

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