Ледостомиг

Prop. INN (наименование, предложенное ВОЗ)

2769743-01-1

immunoglobulin (H-gamma1-scFvhk_L-kappa) dimer, anti-[Homo sapiens NT5E (5'-nucleotidase ecto, 5'-nucleotidase, NT5, eN, eNT, NTE, CALJA, CD73)] and anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], monoclonal antibody, bispecific, tetravalent;
H-gamma1 heavy chain anti-NT5E fused to a scFvhk anti-PDCD1 (1-717) [H-gamma1 heavy chain anti-NT5E (1-451) [VH Musmus/Homsap (Mus musculus IGHV1-42-1*01 (82.7%) -(IGHD) -IGHJ2*01 (100%)/Homo sapiens IGHV1-46*01 (81.6%) -(IGHD) -IGHJ4*01 (86.7%) L123>T (116), V124>L (117), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, 6-G1v14-1 CH2 A1.3, A1.2, A1 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 L1.3>A (238), L1.2>A (239), G1>A (241) (235-344), CH3 D12 (360), L14 (362) (345-449), CHS (450-451)) (122-451)] -20-mer tetrakis(tetraglycyl-seryl) linker (452-471) -scFvhk anti-PDCD1 (472-717) [VH (Homo sapiens IGHV3-23*04 (88.7%) -(IGHD) -IGHJ6*01 (90.9%) T123>L (584), CDR-IMGT [8.8.11] (497-504.522-529.568-578)) (472-589) -20-mer tetrakis(tetraglycyl-seryl) linker (590-609) -V-KAPPA Musmus/Homsap (Mus musculus IGKV14-111*01 (86.3%) -IGKJ5*01 (100%)/Homo sapiens IGKV1-16*01 (80.0%) -IGKJ2*01 (81.8%) Q120>A (709), I126>L (715), CDR-IMGT [6.3.9] (636-641.659-661.698-706)) (610-717)]]; (224-220’)-disulfide with L-kappa light chain anti-NT5E humanized (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (89.1%) -IGKJ2*01 (91.7%) Q120>G (106'), CDR-IMGT [12.3.9] (27'-38'.56'-58'.95'-103')) (1'-113') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (159'), V101 (197')) (114'-220')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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