Лепунафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2396411-71-3

humanized immunoglobulin G1-kappa Fab fragment (1-226) anti-(human transferrin receptor 1) fused via peptidyl linker ²²⁷GGGGSGGGGSGGGGS²⁴¹ to human α-L-iduronidase isoform 1 (242-869), (221-219')-disulfide with kappa light chain (1'-219'), produced in Chinese hamster ovary (CHO) cells, glycoform alfa;
immunoglobulin G1-kappa, humanized Fab fragment targeting the human transferrin receptor 1 (TfR1), fused with human α-L-iduronidase isoform 1, glycoform alfa: gamma1 heavy chain [Homo sapiens IGHV5-51*01; Homo sapiens IGHJ4*01; Homo sapiens IGHG1*01; VH: 1-118; CH1: 119-216; hinge: 217-226; CDR Kabat H1: NYWLG (31-35); CDR Kabat H2: DIYPGGDYPTYSEKFKV (50-66); CDR Kabat H3: SGNYDEVAY (99-107)] (1-226) fused via a (G⁴S)³ peptide linker (227-241) with human α-L-iduronidase (IDUA) isoform 1 (242-869), (221-219')-disulfide with kappa light chain [Homo sapiens IGKV2D-29*02; Homo sapiens IGKJ1*01; Homo sapiens IGKC*01; VL: 1-112; CL: 113-219; CDR Kabat L1: RSSQSLVHSNGNTYLH (24-39); CDR Kabat L2: KVSNRFS (55-61); CDR Kabat L3: SQSTHVPWT (94-102)] (1'-219'), produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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