Лезабелимаб
LesabelimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2475402-56-1
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CD274 (programmed death ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1)], monoclonal antibody;
gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV3-66*01 (79.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.10] (26-33.51-57.98-107)) (1-118) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)], (221-216')-disulfide with kappa light chain (1'-216') [V-KAPPA (Homo sapiens IGKV1-39*01 (92.6%) -IGKJ1*01 (91.7%), CDR-IMGT [6.3.11] (27-32.50-52.89-99)) (1'-109') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (155), V101 (193) (110'-216')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV3-66*01 (79.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.10] (26-33.51-57.98-107)) (1-118) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)], (221-216')-disulfide with kappa light chain (1'-216') [V-KAPPA (Homo sapiens IGKV1-39*01 (92.6%) -IGKJ1*01 (91.7%), CDR-IMGT [6.3.11] (27-32.50-52.89-99)) (1'-109') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (155), V101 (193) (110'-216')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
Структура
Иностранные названия
- Lesabelimabum (латинское)
- Lesabelimab (английское)
- Lesabelimab (немецкое)
- Lésabélimab (французское)
- Lesabelimab (испанское)
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