Летаплимаб
LetaplimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2283356-07-8
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens CD47 (integrin associated protein, IAP, MER6, OA3)], Homo sapiens monoclonal antibody;
gamma4 heavy chain Homo sapiens (1-441) [VH (Homo sapiens IGHV4-59*01 (100%) -(IGHD) -IGHJ1*01 (100%)) CDR-IMGT [8.7.9] (26-33.51-57.96-104) (1-115) -Homo sapiens IGHG4*01, G4v4 CH2 A1.3, A1.2 (CH1 (116-213), hinge 1-12 S10>P (223) (214-225), CH2 F1.3>A (229), L1.2>A (230) (226-335), CH3 (336-440), CHS K>del (441) (116-441)], (129-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (96.8%) -IGKJ4*01 (91.7%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)]; dimer (221-221":224-224")-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-S cell line, glycoform alfa
gamma4 heavy chain Homo sapiens (1-441) [VH (Homo sapiens IGHV4-59*01 (100%) -(IGHD) -IGHJ1*01 (100%)) CDR-IMGT [8.7.9] (26-33.51-57.96-104) (1-115) -Homo sapiens IGHG4*01, G4v4 CH2 A1.3, A1.2 (CH1 (116-213), hinge 1-12 S10>P (223) (214-225), CH2 F1.3>A (229), L1.2>A (230) (226-335), CH3 (336-440), CHS K>del (441) (116-441)], (129-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (96.8%) -IGKJ4*01 (91.7%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)]; dimer (221-221":224-224")-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-S cell line, glycoform alfa
Структура
Иностранные названия
- Letaplimabum (латинское)
- Letaplimab (английское)
- Letaplimab (немецкое)
- Létaplimab (французское)
- Letaplimab (испанское)
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