Лифастузумаб ведотин

Rec. INN (наименование, зарегистрированное ВОЗ)

DB15400

1401812-88-1

immunoglobulin G1-kappa auristatin E conjugate, anti-[Homo sapiens SLC34A2 (solute carrier family 34 sodium phosphate member 2, sodium/phosphate cotransporter 2B, NaPi2b, NaPi3b)], humanized monoclonal antibody conjugated to auristatin E;
gamma1 heavy chain (1-450) [humanized VH (Homo sapiens IGHV3-23*04 (85.70%) -(IGHD)-IGHJ5*01) [8.8.13] (1-120) -Homo sapiens IGHG1*03 (CH1 R120>K (217) (121-218), hinge (219-233), CH2 (234-343), CH3 (344-448), CHS (449-450)) (121-450)], (223- 219')-disulfide with kappa light chain (1'-219') [humanized V-KAPPA (Homo sapiens IGKV1-39*01 (78.00%) -IGKJ1*01) [11.3.9] (1'-112') -Homo sapiens IGKC*01 (113'-219')]; dimer (229-229":232-232")-bisdisulfide; conjugated, on an average of 3 to 4 cysteinyl, to monomethylauristatin E (MMAE), via a cleavable maleimidocaproylvalyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker

C₆₅₀₄H₁₀₀₂₈N₁₇₄₄O₂₀₁₈S₄₆

146416,72 г/моль

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