Лигуфалимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2428381-55-7

immunoglobulin G4-kappa, anti-[Homo sapiens CD47 (integrin associated protein, IAP, MER6, OA3)], monoclonal antibody;
gamma4 heavy chain (1-444) [VH Musmus/Homsap (Mus musculus IGHV1S126*01 (84.7%) -(IGHD) - IGHJ1*01 (100%)/Homo sapiens IGHV1-46*01 (79.6%) -(IGHD) -IGHJ3*01 (85.7%) Q120>A (109), M123>T (112), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117)-Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (118-215), hinge 1-12 S10>P (225) (216-227), CH2 (228-337), CH3 (338-442), CHS (443-444)) (118-444)], (131-214')-disulfide with kappa light chain (1'- 214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV6-20*01 (84.2%) -IGKJ2*01 (100%)/Homo sapiens IGKV3D-7*01 (78.9%) -IGKJ2*01 (91.7%) Q120>G (100), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (223- 223'':226-226'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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