Линклатамиг

Prop. INN (наименование, предложенное ВОЗ)

2885203-43-8

immunoglobulin G1-kappa, anti-[Homo sapiens LY6G6D (lymphocyte antigen 6 family member G6D, G6D, LY6-D, MEGT1, NG25)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], humanized monoclonal antibody, bispecific;
H-gamma1 heavy chain anti-LY6G6D humanized, G1v84-1 VH E44, CH1 K86 (1-442) [VH E44 (Homo sapiens IGHV3-23*01 (77.6%) -(IGHD) -IGHJ2*01 (92.3%) R120>P (104), CDR-IMGT [8.8.5] (26-33.51-58.97-101)) (1-112) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, CH1 K86, G1v30 CH2 G84.4, G1v32 CH3 W22 (knob) (CH1 R120>K (209), S86>K (178) (113-210), hinge 1-15 (211-225), CH2 N84.4>G (292) (226-335), CH3 E12 (351), M14 (353), T22>W (361) (336-440), CHS (441-442)) (123-442)], (215-218')-disulfide with L-kappa light chain humanized, Kv84-1 VK K44, CK E22 (1'-218') [V-KAPPA K44 (Homo sapiens IGKV1-5*01 (89.8%) -IGKJ4*01 (100%), CDR-IMGT [6.3.13] (27'-32'.50'-52'.89'-101')) (1'-111') -Homo sapiens IGKC*01 (99.1%) V22>E (137), Km3 A45.1 (157), V101 (195) (112'-218')];
H-gamma1 heavy chain anti-CD3E humanized, G1v84-2 VH K44, CH1 E86 (1''-449'') [VH K44 (Homo sapiens IGHV1-3*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.12] (26''-33''.51''-58''.97''-108'')) (1''-119'') -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, CH1 E86, G1v30 CH2 G84.4, G1v33 CH3 S22, A24, V86 (hole) (CH1 R120>K (216'') S86>E (185'') (120''-217''), hinge 1-15 (218''-232''), CH2 N84.4>G (299) (233''-342''), CH3 E12 (358''), M14 (360''), T22>S (368''), L24>A (370''), Y86>V (409'') (343''-447''), CHS (448-449'')) (120''-449'')], (222''-219''')-disulfide with L-kappa light chain humanized, Kv84-2 VK E44, CK K22 (1'''-219''') [V-KAPPA E44 (Homo sapiens IGKV4-1*01 (90.8%) -IGKJ1*01 (100%), CDR-IMGT [12.3.8] (27'''-38'''.56'''-58'''.95'''-102''')) (1'''-112''') -Homo sapiens IGKC*01 (99.1%) V22>K (138''), Km3 A45.1 (158'''), V101 (196''') (113'''-219''')]; dimer (221-228'':224-231'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa

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