Линосерпатурев

Prop. INN (наименование, предложенное ВОЗ)

2933092-77-2

recombinant oncolytic herpes simplex virus type 1 (HSV-1) F strain in which both copies of the viral gamma 1 34.5 gene (γ134.5, infected cell protein 34.5 [ICP34.5]) plus the ribonucleoside-diphosphate reductase large subunit UL39 (ICP6 gene) locus have been partially deleted/inactivated and in which a truncated copy of the γ134.5 gene has been re-inserted into the genome in the region of the UL39 (ICP6) deletion in reverse complementary orientation, under transcription control of a glioma-selective murine (Rattus norvegicus) nestin enhancer and a murine (Mus musculus) heat-shock protein 68 (HSP68) minimum gene promoter

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