Литифилимаб
LitifilimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
USAN (наименование, принятое к употреблению в США)
CAS
2407378-48-5
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CLEC4C (C-type lectin domain family 4 member C, CLECSF11, CLECSF7, CD303)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV3-21*01 (85.7%) -(IGHD) -IGHJ5*01 (86.7%), CDR-IMGT [8.8.14] (26-33.51-58.98-111)) (1-122) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 D12 (361), L14 (363) (346-450), CHS K2>del (451)) (123-451)], (225-218')-disulfide with kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV1-39*01 (84.8%) -IGKJ1*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa
gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV3-21*01 (85.7%) -(IGHD) -IGHJ5*01 (86.7%), CDR-IMGT [8.8.14] (26-33.51-58.98-111)) (1-122) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 D12 (361), L14 (363) (346-450), CHS K2>del (451)) (123-451)], (225-218')-disulfide with kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV1-39*01 (84.8%) -IGKJ1*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa
Структура
Иностранные названия
- Litifilimabum (латинское)
- Litifilimab (английское)
- Litifilimab (немецкое)
- Litifilimab (французское)
- Litifilimab (испанское)
Подробнее по теме
Узнайте дополнительные сведения о действующем веществе Литифилимаб: